Dr. Pati was awarded funds to find natural compounds that kill cells that are deficient for BRCA2 as well as validate already identified hits from a pilot screening program. The idea is that one of these compounds could be tested further as a drug that could eliminate BRCA2 deficient cells (those that have lost the normal copy of BRCA2) in humans who carry a BRCA2 mutation before the cells develop into a cancer.
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2017